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Indian J Physiol Pharmacol ; 1979 Apr-Jun; 23(2): 115-20
Article in English | IMSEAR | ID: sea-107457

ABSTRACT

Toxicological study was carried out in rats with chloroform-soluble fraction of the nuts of Semecarpus anacardium to determine its safe non-toxic dose. The fraction produced toxicity at all levels tested (50-400 mg/kg) but the extent of toxicity was found dose-dependent. At lower doses this fraction induced partial growth inhibition over 36 days and higher doses proved fatal within 6 days. It was observed that 230 mg/kg caused 50% mortality in rats and this value is 1380 mg/m2 when expressed for body surface area. This work will be of some use in the cancer chemotherapy study of the fraction.


Subject(s)
Animals , Behavior, Animal/drug effects , Body Weight/drug effects , Lethal Dose 50 , Male , Nuts , Plant Extracts/toxicity , Plants, Medicinal , Rats , Time Factors
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